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Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns3P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.
Gene Name: | tectonin beta-propeller repeat containing 1 |
Synonyms: | TECPR1, KIAA1358, DKFZP434B0335 |
Target Sequences: | NP_056210.1 Q7Z6L1 |
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