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Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).
Gene Name: | TAO kinase 3 |
Family/Subfamily: | Protein Kinase , TAO |
Synonyms: | TAOK3, DPK, JNK/SAPK-inhibitory kinase, Jun kinase-inhibitory kinase, KDS, MAP3K18, Ste20-like kinase, TAO3, TAO kinase 3, HKFC-A, JIK, Kinase from chicken homolog A |
Target Sequences: | NM_016281 NP_057365.3 Q9H2K8 |
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