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Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
Gene Name: | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 |
Synonyms: | STAM, STAM-1, HSE1 homolog, STAM1 |
Target Sequences: | NM_003473 NP_003464.1 Q92783 |
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