MRP14 antibody LS-C96229 is a biotin-conjugated mouse monoclonal antibody to human MRP14 (S100A9). Validated for ELISA and IHC.
Human S100A9 / MRP14
(tested or 100% immunogen sequence identity)
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S100A9 / MRP14 antibody was raised against cultured human monocytes
The antigen is MRP14, the epitope is suspected in the carboxyterminal portion of the peptide. Antigen distribution: Isolated cells: The antigen is found in granulocytes and monocytes. It is absent from all other blood cells. In cultured monocytes, maximum MRP14 expression is found after 3 - 4 days. Myeloid leukaemia cells have been found to be positive as well. Tissue sections: MRP14 is found in a distinct subpopulation of inflammatory perivascular infiltrates of the myelo-monocytic lineage. Macrophages synthesise MRP14 increasingly during the early stages of inflammation. A high MRP14 (and low MRP8) expression by macrophages was reported in granulomatous diseases such as tuberculosis and sarcoidis. In non-granulomatous chronic inflammatory diseases like chronic rheumatoid arthritis, MRP8 and MRP14 positive cells consist of different subpopulations. During early inflammation endothelial cells are also positive with MRP8/14 determined by antibody 27E10. Specificity: Human: MRP14, granulocytes, stimulated monocytes and macrophages. Other: does not react with bovine and swine spleen
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Lyophilized from PBS pH 7.2, 5mg/ml BSA, Kathon
0.5ml distilled water
For research use only.