Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner.
Gene Name: | protein kinase, interferon-inducible double stranded RNA dependent activator |
Synonyms: | PRKRA, DYT16, HSD14, PKR-associating protein X, PACT, PKR-associated protein X |
Target Sequences: | NM_003690 NP_003681.1 O75569 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.