Human PR / Progesterone Receptor

Mouse

Human (tested or 100% immunogen sequence identity)

IgG1 Monoclonal

1A6

Unconjugated

Tissue culture supernatant

Supernatant

Synthetic peptide derived from human progesterone receptor sequence.

Recognizes the human progesterone receptor which is a member of the steroid family of nuclear receptors. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. The detection of estrogen (ER) and progesterone (PR) receptors using immunohistochemical staining of formal fixed paraffin embedded (FFPE) tissue, has gradually replaced ligand binding assays (LBA), to become the most common method for the determination of the ER/PR status of breast tumors. Approximately 75% to 80% of breast tumors have estrogen and/or progesterone receptors, and the presence of these receptors helps determine both the patient's prognosis and the effectiveness of hormonal therapy.

• IHC - Paraffin (1:40)
• Western blot (1:25 - 1:50)

Immunohistology: Immediate fixation in Zamboni's fixative recommended. This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH6.0 is recommended for this purpose.

15mM sodium azide

1 ml Distilled Water.

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P06401 NCBI: NM_000926 AAS00096.1