Rabbit PNN / Pinin

Rabbit

Rabbit, Human (tested or 100% immunogen sequence identity)

IgG,k Recombinant Monoclonal

F12

Unconjugated

Protein A affinity purified

Unmodified

F12 was established by fusing peripheral blood lymphocytes derived from a human vulgaris patient with a hetermyeloma cell line.

F12 recognizes an unknown polypeptide of desmosomal and hemidesmosomal plaques with a MW of 185 kDa (determined from immunoblotting using bovine tongue epithelium extract as the substrate), and by IEM (immunoelectron microscopy) it was determined that it is the intracellular part of the desmosome that is bound (Gilbert, 1997). F12 shares some immunochemical properties with autoantibodiespresent in paraneoplastic pemphigus sera. Pemphigus diseases are those resulting in blistering of the skin due to the production of autoantibodies against keratinocyte surface proteins - autoantibodies of patients with pemphius vulgaris recognize desmoglein 1 (Dsg1), a major glycoprotein of the desmosome complex.

• Immunofluorescence
• Electron Microscopy

Applications should be user optimized.

PBS, 0.02% Proclin 300

Store undiluted at 4°C for up to 3 months. Aliquot and store at -20°C for long term storage.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: Q9H307 NCBI: NM_002687 NP_002678.2