Human PLAP / Alkaline Phosphatase

Rabbit

Human (tested or 100% immunogen sequence identity)

IgG Recombinant Monoclonal

ALPP/2889R

Unconjugated

Protein A/G purified

Azide-free, Carrier-free. Also available Unmodified.

Recombinant full-length human ALPP protein. Antigen Molecular Weight: 70 kDa

Reacts with a 70 kDa membrane-bound isozyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. It is highly specific for PLAP and shows no cross-reaction with other isozymes of alkaline phosphatase. Anti-PLAP reacts with germ cell tumors and can discriminate between these and other neoplasms. Somatic neoplasms e.g. breast, gastrointestinal, prostatic, and urinary cancers may also immunoreact with antibodies to PLAP. Anti-PLAP positivity in conjunction with anti-keratin negativity favors seminoma over carcinoma. Germ cell tumors are usually anti-keratin positive, but they regularly fail to stain with anti-EMA, whereas most carcinomas stain with anti-EMA. Anti-PLAP has been useful in the diagnosis of gestational trophoblastic disease.

• IHC - Paraffin (0.25 - 0.5 µg/ml)

Immunohistology (Formalin-fixed - 0.25-0.5 ug/ml for 30 minutes at RT - No special pretreatment is required for the immunohistochemical staining of formalin-fixed tissues.. Optimal dilution for a specific application should be determined.

10 mM PBS

Store at -20°C to -80°C for up to 2 years.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P05187 NCBI: NM_001632 NP_001623.3