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PIGK is a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme, GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.
Gene Name: | phosphatidylinositol glycan anchor biosynthesis, class K |
Family/Subfamily: | Protease , Cysteine C13 |
Synonyms: | PIGK, GPI transamidase, GPI transamidase subunit, GPI-anchor transamidase, GPI8, GPI8 homolog, HGPI8, PIG-K |
Target Sequences: | NM_005482 NP_005473.1 Q92643 |
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