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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
Gene Name: | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) |
Synonyms: | P4HTM, EGLN4, HIF-PH4, HIF-prolyl hydroxylase 4, p4H with transmembrane domain, PH-4, p4H-TM, HIFPH4, HPH-4, p4HTM, PH4, PHD4, Proline 4-hydroxylase |
Target Sequences: | NM_017732 Q9NXG6 Q9NXG6 |
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