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The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis. The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family.
Gene Name: | PERP, TP53 apoptosis effector |
Synonyms: | PERP, DJ496H19.1, KCP-1, PERP, TP53 apoptosis effector, KCP1, p53-induced protein PIGPC1, THW, KRTCAP1, PIGPC1, RP3-496H19.1, Transmembrane protein THW |
Target Sequences: | NM_022121 NP_071404.2 Q96FX8 |
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