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Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.
Gene Name: | PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) |
Synonyms: | PDS5B, Androgen-induced shutoff 3, AS3, CG008, KIAA0979, APRIN |
Target Sequences: | NM_015032 NP_055847.1 Q9NTI5 |
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