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Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).
Gene Name: | phosphodiesterase 1A, calmodulin-dependent |
Family/Subfamily: | Phosphodiesterase , PDE - cAMP/cGMP dual-specific, Ca/Calmodulin-dependent |
Synonyms: | PDE1A, 61 kDa Cam-PDE, 59 kDa CaM-PDE, Cam-PDE 1A, HCAM-1, HCAM1, HSPDE1A, Phosphodiesterase 1a, CAM-PDE-1A |
Target Sequences: | NM_005019 NP_005010.2 P54750 |
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