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The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene Name: | phosphodiesterase 11A |
Family/Subfamily: | Phosphodiesterase , PDE - cAMP/cGMP dual-specific |
Synonyms: | PDE11A, Pde11, PDE11A4, PDE11A1, PPNAD2, PDE11A2, PDE11A3, Phosphodiesterase 11A |
Target Sequences: | NM_016953 AAI12394.1 Q9HCR9 |
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