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Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space.Dynamin-like 120 kDa protein, form S1: Inactive form produced by cleavage at S1 position by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, leading to negative regulation of mitochondrial fusion.
Gene Name: | optic atrophy 1 (autosomal dominant) |
Synonyms: | OPA1, KIAA0567, MGM1, LargeG, NPG, NTG, Optic atrophy protein 1 |
Target Sequences: | AB011139 BAA25493.1 O60313 |
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