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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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OAS3 / p100 Antibody LS-C502274

P100 antibody LS-C502274 is an unconjugated rabbit polyclonal antibody to human p100 (OAS3). Validated for ELISA, IF and IHC.
Catalog
Size
Price
LS-C502274-50
50 µg
$285
LS-C502274-100
100 µg
$385
Description
P100 antibody LS-C502274 is an unconjugated rabbit polyclonal antibody to human p100 (OAS3). Validated for ELISA, IF and IHC.
Target
Human OAS3 / p100
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated. Also available conjugated with FITC, Biotin, HRP.
Purification
Protein G purified
Modifications
Unmodified
Applications
  • IHC
  • Immunofluorescence
  • ELISA
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
OAS3 / p100 antibody was raised against recombinant Human 2'-5'-oligoadenylate synthase 3 protein (424-565AA)
Specificity
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).
Presentation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Storage
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Restrictions
For research use only.
About OAS3 / p100
Q9Y6K5 NM_006187 NP_006178.2

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Images

Immunohistochemistry

Immunohistochemistry of paraffin-embedded human brain tissue using OAS3 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human brain tissue using OAS3 Antibody at dilution of 1:100

Immunohistochemistry

Immunohistochemistry of paraffin-embedded human testis tissue using OAS3 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis tissue using OAS3 Antibody at dilution of 1:100

Immunofluorescence

Immunofluorescent analysis of A549 cells using OAS3 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Immunofluorescent analysis of A549 cells using OAS3 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Immunohistochemistry

Immunohistochemistry of paraffin-embedded human brain tissue using OAS3 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human brain tissue using OAS3 Antibody at dilution of 1:100

Immunohistochemistry

Immunohistochemistry of paraffin-embedded human testis tissue using OAS3 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis tissue using OAS3 Antibody at dilution of 1:100

Immunofluorescence

Immunofluorescent analysis of A549 cells using OAS3 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Immunofluorescent analysis of A549 cells using OAS3 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Immunohistochemistry

Immunohistochemistry of paraffin-embedded human brain tissue using OAS3 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human brain tissue using OAS3 Antibody at dilution of 1:100

Immunohistochemistry

Immunohistochemistry of paraffin-embedded human testis tissue using OAS3 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis tissue using OAS3 Antibody at dilution of 1:100

Immunofluorescence

Immunofluorescent analysis of A549 cells using OAS3 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Immunofluorescent analysis of A549 cells using OAS3 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Immunohistochemistry

Immunohistochemistry of paraffin-embedded human brain tissue using OAS3 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human brain tissue using OAS3 Antibody at dilution of 1:100

Immunohistochemistry

Immunohistochemistry of paraffin-embedded human testis tissue using OAS3 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis tissue using OAS3 Antibody at dilution of 1:100

Immunofluorescence

Immunofluorescent analysis of A549 cells using OAS3 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Immunofluorescent analysis of A549 cells using OAS3 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Requested From: United States
Date Requested: 4/20/2019
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