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| Catalog Number | Size | Price |
|---|---|---|
| LS-C499428-50 | 50 µg | $294 |
| LS-C499428-100 | 100 µg | $360 |
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Polyclonal Rabbit anti‑Human NF2 / Merlin Antibody (IHC, IF, WB) LS‑C499428
Polyclonal Rabbit anti‑Human NF2 / Merlin Antibody (IHC, IF, WB) LS‑C499428
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Specifications
Description
Merlin antibody LS-C499428 is an unconjugated rabbit polyclonal antibody to Merlin (NF2) from human. It is reactive with human and mouse. Validated for ELISA, IF, IHC and WB.
Target
Human NF2 / Merlin
Synonyms
NF2 | ACN | BANF | Moesin-ezrin-radixin like | Neurofibromin 2 (merlin) | Neurofibromin-2 | SCH | Merlin | Schwannomerlin | Schwannomin
Host
Rabbit
Reactivity
Human, Mouse
(tested or 100% immunogen sequence identity)
Clonality
IgG
Polyclonal
Purification
Protein G purified
Modifications
Unmodified
Immunogen
Recombinant human Merlin protein (230-414AA)
Specificity
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.
Applications
- IHC
- Immunofluorescence
- Western blot
- ELISA
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Storage
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About NF2 / Merlin
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Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/27/2024
Date Requested: 4/27/2024
