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MTIF2

mitochondrial translational initiation factor 2

During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene.

Gene Name: mitochondrial translational initiation factor 2
Synonyms: MTIF2, IF-2(Mt), IF-2mt, IF2(mt)
Target Sequences: NM_002453 NP_002444.2 P46199

Publications (2)

1
Fidelity of translation initiation is required for coordinated respiratory complex assembly. Rudler DL, Hughes LA, Perks KL, Richman TR, Kuznetsova I, Ermer JA, Abudulai LN, Shearwood AJ, Viola HM, Hool LC, Siira SJ, Rackham O, Filipovska A. Science advances. 2019 December;5: [Full Text Article] [PubMed:31903419] [PMC:PMC6924987]
2
Stress signaling and cellular proliferation reverse the effects of mitochondrial mistranslation. Nicola Ferreira, Kara L Perks, Giulia Rossetti, Danielle L Rudler, Laetitia A Hughes, Judith A Ermer, Louis H Scott, Irina Kuznetsova, Tara R Richman, Vinod K Narayana, Laila N Abudulai, Anne-Marie J Shearwood, Henrietta Cserne Szappanos, Dedreia Tull, George C Yeoh, Livia C Hool, Aleksandra Filipovska, Oliver Rackham. The EMBO journal. 2019 December;38:e102155. [Full Text Article] [PubMed:31721250] [PMC:PMC6912024]

☰ Filters
Antibodies (17)
Proteins (5)
Over-Expression Lysate (4)
Primary (17)
Recombinant (1)
MTIF2 (22)
Human (17)
Mouse (2)
Rat (9)
IHC (2)
IHC-P (1)
WB (16)
ELISA (7)
IF (1)
rabbit (17)
Product Group
IHCPlus (1)
IgG (7)
polyclonal pc (17)
APC (1)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (2)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (2)
Unconjugated (5)
aa138-167 (7)
No (22)
Myc-DDK (Flag) (4)
Human (2)
Rat (1)
293T Cells (2)
E. coli (1)
HEK 293 Cells (2)
Purified (1)
MTIF2 Antibody - Anti-MTIF2 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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MTIF2 Rabbit anti-Human Polyclonal (aa138-167) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
MTIF2 Antibody - Immunohistochemistry of paraffin-embedded Human lung cancer using MTIF2 Polyclonal Antibody at dilution of 1:100 (40x lens).
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MTIF2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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MTIF2 Rabbit anti-Human Polyclonal (aa138-167) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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MTIF2 Rabbit anti-Human Polyclonal (aa138-167) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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MTIF2 Rabbit anti-Human Polyclonal (aa138-167) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
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MTIF2 Rabbit anti-Human Polyclonal (aa138-167) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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MTIF2 Rabbit anti-Human Polyclonal (aa138-167) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
MTIF2 Rabbit anti-Human Polyclonal (aa138-167) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
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MTIF2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
MTIF2 Antibody - Western Blot; Sample: Recombinant protein.
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MTIF2 Rabbit anti-Rat Polyclonal Antibody
Rat, Human
WB
Unconjugated
100 µl/$317; 200 µl/$363; 500 µl/$515; 1 ml/$591; 2 ml/$816; 5 ml/$1,331
MTIF2 Antibody - Western Blot; Sample: Recombinant protein.
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MTIF2 Rabbit anti-Rat Polyclonal (HRP) Antibody
Rat, Human
WB
HRP Conjugated
100 µl/$349; 200 µl/$408; 500 µl/$609; 1 ml/$762; 2 ml/$999; 5 ml/$1,729
MTIF2 Antibody - Western Blot; Sample: Recombinant protein.
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MTIF2 Rabbit anti-Rat Polyclonal (Biotin) Antibody
Rat, Human
WB
Biotin Conjugated
100 µl/$328; 200 µl/$378; 500 µl/$545; 1 ml/$645; 2 ml/$879; 5 ml/$1,464
MTIF2 Antibody - Western Blot; Sample: Recombinant protein.
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MTIF2 Rabbit anti-Rat Polyclonal (FITC) Antibody
Rat, Human
WB
FITC Conjugated
100 µl/$359; 200 µl/$423; 500 µl/$655; 1 ml/$816; 2 ml/$1,055; 5 ml/$1,863
MTIF2 Antibody - Western Blot; Sample: Recombinant protein.
Select
MTIF2 Rabbit anti-Rat Polyclonal (APC) Antibody
Rat, Human
WB
APC Conjugated
100 µl/$423; 200 µl/$515; 500 µl/$906; 1 ml/$1,071; 2 ml/$1,420; 5 ml/$2,661
MTIF2 Antibody - Western Blot; Sample: Recombinant protein.
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MTIF2 Rabbit anti-Rat Polyclonal (PE) Antibody
Rat, Human
WB
PE Conjugated
100 µl/$423; 200 µl/$515; 500 µl/$906; 1 ml/$1,071; 2 ml/$1,420; 5 ml/$2,661
MTIF2 Antibody - Western Blot; Sample: Recombinant protein.
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MTIF2 Rabbit anti-Rat Polyclonal (APC, Cy7) Antibody
Rat, Human
WB
APC, Cy7 Conjugated
100 µl/$530; 200 µl/$703; 500 µl/$1,217; 1 ml/$1,521; 2 ml/$2,129; 5 ml/$3,991
MTIF2 Antibody - Western Blot; Sample: Recombinant protein.
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MTIF2 Rabbit anti-Rat Polyclonal (Cy3) Antibody
Rat, Human
WB
Cy3 Conjugated
100 µl/$423; 200 µl/$515; 500 µl/$906; 1 ml/$1,071; 2 ml/$1,420; 5 ml/$2,661
MTIF2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
81.34 kDa
100 µg/$710
MTIF2 Protein - Recombinant Mitochondrial Translational Initiation Factor 2 (MTIF2) by SDS-PAGE
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E. coli
None
53.1kDa
10 µg/$273; 50 µg/$392; 200 µg/$782; 100 µg/$625; 1 mg/$1,847; 500 µg/$1,404; 5 mg/$2,807; 2 mg/$2,029
MTIF2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
81.34 kDa
100 µg/$710
MTIF2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
81.34 kDa
20 µg/$215
MTIF2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
81.34 kDa
20 µg/$215
Viewing 1-22 of 22 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).