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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MICA/B Antibody (Low Endotoxin) LS‑C44799
B antibody LS-C44799 is an unconjugated mouse monoclonal antibody to human B (MICA). Validated for Flow, Func, IHC and IP.
Catalog
Size
Price
LS-C44799-500
500 µg (1 mg/ml)
$495
Description
B antibody LS-C44799 is an unconjugated mouse monoclonal antibody to human B (MICA). Validated for Flow, Func, IHC and IP.
Target
Human MICA/B
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG2a Monoclonal
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Low Endotoxin. Also available Unmodified.
Applications
  • IHC
  • IHC - Frozen (1:100)
  • Immunoprecipitation
  • Flow Cytometry
  • Functional Assay
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
MICA/B antibody was raised against mICA transfected C1R cells.
Specificity
Specific for nonclassical MHC class I chain A (MICA) and nonclassical MHC class I chain MICB (MICB). MICA and MICB are stress inducible antigens, which are closely related and appear functionally indistinguishable. MICA and MICB are ligands for NKG2D, an activating receptor on most natural killer (NK) cells, CD8 T cells and gamma delta T cells. MICA is principally expressed on intestinal epithelium, and several epithelial tumors. Expression may be induced to high surface levels by heat shock, oxidative stress, and virus infection. Clone 6D4 is reported to inhibit the cytotoxicity of NK cells stimulated by IFN alpha-treated dendritic cells.
Usage
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. Flow Cytometry: Use 10 ul of the suggested working dilution to label 1x10^6 cells in 100 ul. Method sheets are available on request. Membrane permeabilization is required for this application.
Presentation
PBS, pH 7.4
Restrictions
For research use only.

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Requested From: United States
Date Requested: 12/9/2018
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