Human MHC Class I

Mouse

Human (tested or 100% immunogen sequence identity)

IgG2a Monoclonal

BRA-23/9

Unconjugated

Purified

Unmodified

BRA-23/9 is a mouse monoclonal IgG2a antibody derived by fusion of mouse myeloma cells with cells from a mouse immunized with REH cells, a human pre-B cell leukaemia cell line.

The antibody BRA-23/9 is directed against a non-polymorphic determinant of human HLA Class I. The antibody has not been tested for cross reactivity with other species.

• IHC
• IHC - Frozen
• Flow Cytometry

The major histocompatibility complex (MHC) is a cluster of genes that play an important role in the immune response. In humans, this complex is referred to as the Human Leucocyte Antigen (HLA) system. There are three major HLA class I genes which are HLA-A, HLA-B and HLA-C. These are highly polymorphic and thousands of alleles are known to exist. The HLA-A, B and C gene products are heterodimeric cell surface glycoproteins which all consist of a 40-45kD MHC-encoded alpha chain and a non-covalently linked non-MHC encoded light chain (b2-microglobulin) of 12kD. These proteins are found on the surface of almost all nucleated cells and their role is to present peptides, produced by intracellular protein degradation, to cytotoxic T lymphocytes and natural killer cells.

PBS, 50% glycerol, 0.2% BSA, 0.02% sodium azide

Short term: 4°C; Long term: -20°C; Protect from light.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.