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Catalog Number Size Price
LS-C42649-50 50 µg (0.5 mg/ml) $363 
Antibody

Polyclonal Rabbit anti‑Mouse MDM2 Antibody (aa177‑195, WB) LS‑C42649

Polyclonal Rabbit anti‑Mouse MDM2 Antibody (aa177‑195, WB) LS‑C42649

Antibody:
MDM2 Rabbit anti-Mouse Polyclonal (aa177-195) Antibody
Application:
WB, ELISA
Reactivity:
Mouse
Format:
Unconjugated, Unmodified
Price
Catalog Number
$363
LS-C42649-50
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
MDM2 Rabbit anti-Mouse Polyclonal (aa177-195) Antibody
Application:
WB, ELISA
Reactivity:
Mouse
Format:
Unconjugated, Unmodified

Specifications

Description
MDM2 antibody LS-C42649 is an unconjugated rabbit polyclonal antibody to mouse MDM2 (aa177-195). Validated for ELISA and WB.
Target
Mouse MDM2
Synonyms
MDM2 | ACTFS | Double minute 2 protein | Hdm2 | MDM2 variant FB30 | HDMX | Oncoprotein Mdm2 | p53-binding protein Mdm2 | MDM2 variant FB28
Host
Rabbit
Reactivity
Mouse (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Purified IgG
Modifications
Unmodified
Immunogen
Synthetic peptide corresponding to aa 177-195 of mouse Mdm2.
Epitope
aa177-195
Specificity
Detects murine Mdm2, a nuclear phosphoprotein that controls intracellular levels of the tumor suppressor protein p53 by ubiquitination and subsequent proteasomal degradation. Mdm2 also interacts with the retinoblastoma (RB) protein and E2F-1, to promote G1-S phase transition in the cell cycle. Mdm2 activity is controlled by self-ubiquitination; however activation of the PI3K/PKB pathway leads to phosphorylation of Mdm2 at Ser185, which stabilizes the protein.
Applications
  • Western blot (1:500 - 1:2000)
  • ELISA (1:3000 - 1:12000)
Usage
Western Blot: LS-C42649 detects a band of approximately 90kD in mouse MEF cell lysates.
Presentation
PBS, 0.09% Sodium Azide
Storage
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About MDM2
Q00987 NM_002392 NP_002383.2

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/17/2021