Human MAP2K3 / MEK3 / MKK3

Rabbit

Human, Mouse, Rat, Dog, Guinea pig, Hamster, Horse (tested or 100% immunogen sequence identity)

Bovine, Rabbit, Sheep (at least 90% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Immunoaffinity purified

Unmodified

Synthetic peptide from the C-Terminus of human MEK3 (MEHPFFTLHKTKKTD, aa320-334 of UniProt P46734). Percent identity by BLAST analysis: Human, Mouse, Rat, Ferret, Cat, Hamster, Elephant, Horse, Guinea pig, Dog (100%); Sheep, Bovine, Rabbit, Opossum (93%); Zebra finch, Chicken, Platypus (87%).

aa320-334

Human MAP2K3 / MEK3 / MKK3

• IHC
• IHC - Paraffin (0.5 - 1 µg/ml)
• Western blot (0.5 - 1 µg/ml)

Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. Rampoldi et al. (1997) localized the MAP2K3 gene to 17q11.2.

Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.

Reconstitute in sterile distilled water.

Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P46734 NCBI: NM_002756 NP_002747.2