Target
Human KISS1R / GPR54
Synonyms
KISS1R | AXOR12 | GPR54 | HOT7T175 | KISS-1R | KISS1 receptor | G protein-coupled receptor 54 | Metastin receptor | Rot7t175 | G-protein coupled receptor 54 | HH8 | Hypogonadotropin-1 | KiSS-1 receptor | Kisspeptins receptor
Reactivity
Human
(tested or 100% immunogen sequence identity)
Immunogen
A synthetic peptide corresponding to a sequence of human KiSS1 receptor (MLRHLGRVAVRPAPADSALQGQVLAERAGAVRAK).
Specificity
Most highly expressed in the pancreas, placenta and spinal cord, with lower-level of expression in peripheral blood leukocytes, kidney, lung, fetal liver, stomach, small intestine, testes, spleen, thymus, adrenal glands and lymph nodes. In the adult brain, expressed in the superior frontal gyrus, putamen, caudate nucleus, cingulate gyrus, nucleus accumbens, hippocampus, pons and amygdala, as well as the hypothalamus and pituitary. Expression levels are higher in early (7-9 weeks) than term placentas. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation. Also found in the extravillous trophoblast suggesting endocrine/paracrine activation mechanism.