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Catalog Number Size Price
LS-C744235-5 5 ml $465 
Antibody

Monoclonal Mouse Keratin, HMW + p63 Antibody (IHC) LS‑C744235

Monoclonal Mouse Keratin, HMW + p63 Antibody (IHC) LS‑C744235

Antibody:
Keratin, HMW + p63 Mouse Monoclonal Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$465
LS-C744235-5
Toll Free North America
206-374-1102
For Research Use Only

Overview

Antibody:
Keratin, HMW + p63 Mouse Monoclonal Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
Keratin, HMW + p63 antibody LS-C744235 is an unconjugated mouse monoclonal antibody to human Keratin, HMW + p63. Validated for IHC.
Target
Keratin, HMW + p63
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 + IgG2a Monoclonal
Conjugations
Unconjugated
Modifications
Unmodified
Immunogen
Recombinant human p63 protein (aa 1-205) and cytokeratin extract of human stratum corneum
Applications
  • IHC - Paraffin
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Use formalin-fixed and paraffin-embedded sections; Retrieval conditions: antigen retrieval, TEC buffer (Tris/EDTA/Citrate) pH 8 in a pressure cooker at 100°C 20-40 minutes The p63 protein, a homologue of the tumour-suppressor p53, is highly expressed in the nuclei of basal or progenitor layer of many epithelial tissues. p63 is detected in prostate basal cells in normal prostate glands and PIN. Other markers for basal cells are high molecular cytokeratins (CK 1, 5, 10 and 14), which can be labelled with HMW CK clone 34ßE12. In prostate adenocarcinoma basal cells disappear and staining with both p63 and HMW CK fails. Thus the combination of p63 and HMW CK is a useful tool as differential markers for benign prostate glands and adenocarcinoma (negative marker). nuclear p63 and cytoplasmic high molecular weight cytokeratins.
Presentation
PBS, pH 7.3, 0.09% Sodium Azide
Storage
Store at 2°C to 8°C.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/29/2022