Rabbit ITGB7 / Integrin Beta 7

Rabbit

Rabbit, Human, Mouse (tested or 100% immunogen sequence identity)

IgG,k Recombinant Monoclonal

FIB27

Unconjugated

Protein A affinity purified

Unmodified

FIB27 was prepared by immunizing rats with TK1 cells.

FIB27 binds specifically to both human and mouse integrin beta-7 at epitope region Dl on which is involved in all a4b7-mediated adhesion events. Does not compete with DAKT32 for binding. FIB27 blocks LS722-induced TK1 cell aggregation (mAb LS722 is an activating anti-a4B7 antibody and induces aggregation via an a4B7-dependent pathway). Integrin beta-7 is one subunit is a heterodimer which makes up an intergin molecule. In the mouse beta-7 is selectively found on the majority of mature lymphocytes, whereas a small subpopulation of thymocytes and bone marrow cells express beta-7. Beta-7 is also expressed in variable amounts in CD4 T memory cells. Integrin molecules mediate cell-cell and cell-extracellular matrix adhesion and are involved in lymphocyte homing, leukocyte recruitment to inflammatory sites, myogenesis, hemopoiesis, and melanoma metastasis.

• Immunoprecipitation
• Flow Cytometry
• Blocking

Applications should be user optimized.

PBS, 0.02% Proclin 300

Store undiluted at 4°C for up to 3 months. Aliquot and store at -20°C for long term storage.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P26010 NCBI: NM_000889 NP_000880.1