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INSL3 is a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants.
Gene Name: | insulin-like 3 (Leydig cell) |
Family/Subfamily: | Hormone , not assigned-Hormone |
Synonyms: | INSL3, Insulin-like 3 (Leydig cell), Insulin-like 3, Ley-I-L, Leydig insulin-like peptide, Relaxin-like factor, RLNL, Tyrosine protein kinase jak3m, Relaxin-like factor b, Leydig insulin -like hormone |
Target Sequences: | NM_005543 NP_005534.2 |
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