Human IL23A / IL-23 p19

Mouse

Human (tested or 100% immunogen sequence identity)

IgG1 Recombinant Monoclonal

mh066

Unconjugated

Protein A purified

Preservative Free

Recombinant Human IL23A & Mouse IL12B Heterodimer Protein

Human IL-23. Has cross-reactivity with with Cynomolgus IL-23 & IL12B Heterodimer Protein in ELISA assay. No cross-reactivity with Mouse IL-23 & IL12B Heterodimer or Rat IL-23 & IL12B Heterodimer Protein in ELISA assay

• ELISA (8 µg/ml)
• Neutralization (10 ng/ml)

Block: In a functional ELISA which immobilized recombinant Human IL23R/Fc Chimera at 8 ug/ml (100 µL/well) in the plate, the Rabbit anti-Human IL23a Monoclonal Antibody can block the binding of 0.5 ug/ml of biotinylated recombinant Human IL23A & Human IL12B Heterodimer Protein to human IL23R, the EC50 is 0.59 ug/ml. Neutralization: The neutralization activity of antibody is Measured by its ability to neutralize IL23­induced IL17A secretion in mouse splenocytes. The Neutralization titer (IC50) is typically 10.0­15.0 ng/mL in the presence of 10 ng/mL Recombinant Human IL-23 and ConA (1 µg/mL ). Please Note: Optimal concentrations/dilutions should be determined by the end user.

0.2 µm filtered histidine and arginine buffer containing 120mM NaCl, 0.02% Tween 80, pH 6.0

Store at 2°C to 8°C for up to 1 month. Aliquot and store at -20°C to -80°C for up to 1 year. Avoid freeze/thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: Q9NPF7 NCBI: NM_016584 NP_057668.1