IL1RL1 | DER4 | Growth stimulation-expressed | IL33R | Interleukin-1 receptor-like 1 | Interleukin 1 receptor-like 1 | ST2 | ST2L | ST2V | FIT-1 | Protein ST2 | ST2 protein | IL-1R4 | IL1R4
(tested or 100% immunogen sequence identity)
A 16 AA synthetic peptide located near mouse ST2 N-Terminus. This peptide is common to the three known isoforms of ST2.
Recognizes an epitope within the N-Terminal region (NT) of mouse ST2, a member of the Toll-interleukin 1 receptor (TIR) superfamily, expressed by mast cells and TH2 helper cells, but not by TH1 effector cells. The majority of TIR superfamily members, which includes the Interleukin-1 receptor (IL-1R1), Toll-like receptors (TLRs) and the cytosolic adaptor proteins MyD88, TIRAP, Trif and TRAM, initiate innate immunity through the ultimate activation of the transcription factor NF-kappaB and are inducers of the inflammatory response. In contrast ST2, which itself is unable to activate NF-kappaB, has been identified as a negative regulator of IL-1R1 and TLR4 signaling by sequestering MyD88 and TIRAP in line with its role as a crucial receptor in TH2-cell mediated responses and.