Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
IL-1 Beta antibody LS-C42757 is an unconjugated rabbit polyclonal antibody to sheep IL-1 Beta (IL-1B). Validated for ELISA and WB. Cited in 1 publication.
About IL-1B / IL-1 Beta
IL-1 Beta is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.
(tested or 100% immunogen sequence identity)
Recombinant IL-1 beta.
Recognizes ovine interleukin-1 beta (IL-1 beta). No cross-reactivity is seen with ovine IL-6, IL-8, MCP-1 or TNF alpha. Neutralizes the bioactivity of ovine IL-1 beta. Removal of sodium azide is recommended prior to use in functional assays.
Serum, 0.1% Sodium Azide
Store at 4°C or -20°C. Avoid freeze-thaw cycles. Store undiluted.
Ontogeny and the effects of in utero brain ischemia on interleukin-1 beta and interleukin-6 protein expression in ovine cerebral cortex and white matter. Sadowska GB, Threlkeld SW, Flangini A, Sharma S, Stonestreet BS. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2012 Oct;30:457-63. [Full Text Article]