Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
IL-1 Beta antibody LS-C7712 is an unconjugated mouse monoclonal antibody to human IL-1 Beta (IL-1B). Validated for ELISA.
About IL-1B / IL-1 Beta
IL-1 Beta is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.
(tested or 100% immunogen sequence identity)
Ion exchange chromatography
Recombinant human IL-1b.
Recognizes human IL-1b.
Direct ELISA. Direct ELISA: 1:10000 dilution will yield 0.2 O. D. using alkaline phosphatase conjugated rabbit anti-mouse Ig. A 1:2000 dilution will completely inhibit a thymocyte co-stimulation assay using suboptimal doses of Concanavalin A.
500 µl deionized water
Short term: 4°C; Long term: Add glycerol (40-50%) -20°C.