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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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Catalog Number Size Price
LS-B7134-100 100 µg (1 mg/ml) $425 
CEACAM8 / CD66b Antibody - Anti-CEACAM8 / CD66b antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

IHCPlus™ Monoclonal CEACAM8 / CD66b Antibody (clone 80H3, IHC) LS‑B7134

IHCPlus™ Monoclonal CEACAM8 / CD66b Antibody (clone 80H3, IHC) LS‑B7134

Note: This antibody replaces LS-C44340, LS-C44355
Antibody:
Mouse Monoclonal to Human CEACAM8 / CD66b
Application:
IHC, IHC-P, IHC-Fr, Flo
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-B7134-100
100 µg
1 mg/ml
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Mouse Monoclonal to Human CEACAM8 / CD66b
Application:
IHC, IHC-P, IHC-Fr, Flo
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
CD66b antibody LS-B7134 is an unconjugated mouse monoclonal antibody to human CD66b (CEACAM8). Validated for Flow and IHC. Tested on 20 paraffin-embedded human tissues. Cited in 4 publications.
Target
Human CEACAM8 / CD66b
Synonyms
CEACAM8 | CD66b antigen | Carcinoembryonic antigen CGM6 | CD67 | CD67 antigen | CGM6 | NCA-95 | CD66b
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal
Clone
80H3
Conjugations
Unconjugated. Also available conjugated with FITC.
Purification
Protein A purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (10 µg/ml)
  • IHC - Frozen (1:25 - 1:100)
  • Flow Cytometry (1:50 - 1:100)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
CML leucocytes.
Specificity
Reacts with the CGM6 gene product of the carcinoembryonic gene family. This is a 95-100kD GPI anchored molecule. CD66b is expressed strongly by mature granulocytes and metamyelocytes, and weakly by bone marrow myelocytes. CD66b is not expressed by peripheral blood monocytes or lymphocytes.
Usage
Flow Cytometry: Use 10 ul of the suggested working dilution to label 5 x 10^5 cells or 100 ul whole blood.
Presentation
PBS, 0.09% Sodium Azide, 0.5% BSA
Storage
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CEACAM8 / CD66b
P31997 NM_001816 NP_001807.2

Validation

CEACAM8 / CD66b Antibody - Anti-CEACAM8 / CD66b antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-CEACAM8 / CD66b antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-CEACAM8 / CD66b antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

LSBio Ratings

IHC-plus™ CEACAM8 / CD66b Antibody (clone 80H3) for IHC, Flow LS-B7134 has an LSBio Rating of
Publications (4.3)
Laboratory Validation Score (4)

Publications (4)

Tumor-Infiltrating Immune Cells Are Associated With Prognosis of Gastric Cancer. Liu K, Yang K, Wu B, Chen H, Chen X, Chen X, Jiang L, Ye F, He D, Lu Z, Xue L, Zhang W, Li Q, Zhou Z, Mo X, Hu J. Medicine. 2015 94:e1631. (IHC; Human)

Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies. Hossain F, Al-Khami AA, Wyczechowska D, Hernandez C, Zheng L, Reiss K, Valle LD, Trillo-Tinoco J, Maj T, Zou W, Rodriguez PC, Ochoa AC. Cancer immunology research. 2015 3:1236-47. (IHC; Human)

The Differential Contribution of the Innate Immune System to a Good Pathological Response in the Breast and Axillary Lymph Nodes Induced by Neoadjuvant Chemotherapy in Women with Large and Locally Advanced Breast Cancers. Kaewkangsadan V, Verma C, Eremin JM, Cowley G, Ilyas M, Satthaporn S, Eremin O. Journal of immunology research. 2017 2017:1049023. (Human)

Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells. Al-Khami AA, Zheng L, Del Valle L, Hossain F, Wyczechowska D, Zabaleta J, Sanchez MD, Dean MJ, Rodriguez PC, Ochoa AC. Oncoimmunology. 2017 June;6:e1344804.

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Requested From: United States
Date Requested: 3/31/2020