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Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.
Gene Name: | tripartite motif containing 32 |
Family/Subfamily: | Tripartite Motif |
Synonyms: | TRIM32, 72 kDa Tat-interacting protein, HT2A, LGMD2H, TATIP, Tripartite motif containing 32, Zinc finger protein HT2A, Zinc-finger protein HT2A, TAT-interactive protein, 72-KD, BBS11, Tripartite motif-containing 32 |
Target Sequences: | NM_012210 NP_036342.2 Q13049 |
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