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GTF2H3 is a member of the TFB4 family. The encoded protein is a subunit of the core-TFIIH basal transcription factor and localizes to the nucleus. The encoded protein is involved in RNA transcription by RNA polymerase II and nucleotide excision repair and associates with the Cdk-activating kinase complex. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 14.
Gene Name: | general transcription factor IIH, polypeptide 3, 34kDa |
Synonyms: | GTF2H3, BTF2, BTF2 p34, p34, TFIIH, TFB4 |
Target Sequences: | NM_001516 NP_001507.2 Q13889 |
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