Rat GRIA2 / GLUR2
GRIA2 | AMPA 2 | GluR-K2 | Glutamate receptor 2 | HBGR2 | GluA2 | GluR-2 | GluR-B | GLUR2 | GLURB
(tested or 100% immunogen sequence identity)
Keyhole limpet hemocyanin conjugated synthetic peptide corresponding to an amino acid sequence within rat GluR2.
Recognizes glutamate receptor subunit 2 (GluR2), a component of the AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid) group of ionotropic glutamate receptors, which play a key role at excitatory synapses, including synaptic transmission, stabilization and plasticity. GluR2 is possibly the most important of the AMPA receptor subunits, responsible for AMPA receptor rectifying properties, control of ion flow and in particular the influx of calcium. The majority of GluR2 in the CNS is expressed in the GluR2(R) form, containing a critical arginine residue (as opposed to a glutamine residue) in the Transmembrane region 2 (TM2) domain, thereby rendering native AMPA receptors impermeable to calcium.