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Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca2+ and Mg2+. Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids.
Gene Name: | G protein-coupled receptor, class C, group 6, member A |
Family/Subfamily: | GPCR , Amino Acid Receptor |
Synonyms: | GPRC6A, BA86F4.3, HGPCR33, HGPRC6A, Predicted with SOSUI analysis |
Target Sequences: | NM_148963 NP_683766.2 Q5T6X5 |
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