Rat GJB3 / CX31 / Connexin 31
GJB3 | Connexin 31 | Connexin-31 | CX31 | DFNA2 | Erythrokeratodermia variabilis | Gap junction beta-3 protein | DFNA2B | EKV | Gap junction protein beta 3
(tested or 100% immunogen sequence identity)
Synthetic phosphopeptide corresponding to an amino acid sequence within connexin43 which includes phosphorylated Ser368 (pSer368).
Recognizes the ~43 kD Connexin43, when phosphorylated at Ser368. Connexin43 (CX43) allows for the exchange of solutions between neighboring cells through the formation of gap-junctional channels and is expressed in the brain, kidneys and myocardium, as well as vascular endothelial cells. A decrease in the permeability of gap-junctional channels occurs due to a conformational change in the structure of CX43, and that this is mediated by the phosphorylation of CX43 at residue Ser368, by Protein Kinase C. A possible link between CX43 and epilepsy has been investigated following the detection of high levels of CX43 in both low-grade tumors and peritumoural reactive astrocytes.