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Catalog Number Size Price
LS-C43142-0.1 0.1 ml $525 
Antibody

Monoclonal Rabbit anti‑Rat GJB3 / CX31 / Connexin 31 Antibody (phospho‑Ser368, WB) LS‑C43142

Monoclonal Rabbit anti‑Rat GJB3 / CX31 / Connexin 31 Antibody (phospho‑Ser368, WB) LS‑C43142

Antibody:
GJB3 / CX31 / Connexin 31 Rabbit anti-Rat Monoclonal (pSer368) Antibody
Application:
WB
Reactivity:
Rat
Format:
Unconjugated, Unmodified
Price
Catalog Number
$525
LS-C43142-0.1
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
GJB3 / CX31 / Connexin 31 Rabbit anti-Rat Monoclonal (pSer368) Antibody
Application:
WB
Reactivity:
Rat
Format:
Unconjugated, Unmodified

Specifications

Description
Connexin 31 antibody LS-C43142 is an unconjugated rabbit monoclonal antibody to rat Connexin 31 (GJB3 / CX31) (pSer368). Validated for WB.
Target
Rat GJB3 / CX31 / Connexin 31
Synonyms
GJB3 | Connexin 31 | Connexin-31 | CX31 | DFNA2 | Erythrokeratodermia variabilis | Gap junction beta-3 protein | DFNA2B | EKV | Gap junction protein beta 3
Host
Rabbit
Reactivity
Rat (tested or 100% immunogen sequence identity)
Clonality
IgG Monoclonal
Conjugations
Unconjugated
Purification
Purified
Modifications
Unmodified
Immunogen
Synthetic phosphopeptide corresponding to an amino acid sequence within connexin43 which includes phosphorylated Ser368 (pSer368).
Epitope
pSer368
Specificity
Recognizes the ~43 kD Connexin43, when phosphorylated at Ser368. Connexin43 (CX43) allows for the exchange of solutions between neighboring cells through the formation of gap-junctional channels and is expressed in the brain, kidneys and myocardium, as well as vascular endothelial cells. A decrease in the permeability of gap-junctional channels occurs due to a conformational change in the structure of CX43, and that this is mediated by the phosphorylation of CX43 at residue Ser368, by Protein Kinase C. A possible link between CX43 and epilepsy has been investigated following the detection of high levels of CX43 in both low-grade tumors and peritumoural reactive astrocytes.
Applications
  • Western blot (1:1000)
Usage
Western Blot: LS-C43142 detects a band of approximately 43kD in rat hippocampus cell lysates.
Presentation
10mM HEPES, pH 7.5, 0.05% Sodium Azide, 50% Glycerol, 0.01% BSA
Storage
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About GJB3 / CX31 / Connexin 31
O75712 NM_024009 NP_076872.1

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/19/2021