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GABRG3 is a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. The protein encoded by this gene is a gamma subunit, which contains the benzodiazepine binding site. Two transcript variants encoding distinct isoforms have been found for this gene.
Gene Name: | gamma-aminobutyric acid (GABA) A receptor, gamma 3 |
Family/Subfamily: | Ion Channel , GABA A receptor |
Synonyms: | GABRG3, Gamma 3, GABA A receptor gamma 3, GABA(G) receptor, gamma 3 |
Target Sequences: | NM_033223 NP_150092.2 Q99928 |
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