Human FLT3LG / Flt3 Ligand
FLT3LG | FL | Flt3 ligand | FLT3L | SL cytokine
(tested or 100% immunogen sequence identity)
Recombinant human Flt3-Ligand.
Recognizes the ubiquitously expressed human growth factor Flt3-Ligand (Flt3L), a 235aa type I transmembrane glycoprotein which regulates the proliferation of early hematopoietic cells. Flt3L exists in both a membrane-bound and proteolytically cleaved soluble isoform, both of which are biologically active, and initiates cell proliferation/ differentiation signalling in co-operation with other colony stimulating factors (CSFs) and interleukins, by binding to and activating the tyrosine kinase receptor Flt3 (FLT3R), expressed highly by hematopoietic progenitor cells and stem cells.