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Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene.
Gene Name: | fibrinogen-like 1 |
Synonyms: | FGL1, Fibrinogen-like 1, Hepassocin, HFREP-1, HFREP1, HP-041, LFIRE-1, Fibrinogen-like protein 1, LFIRE1 |
Target Sequences: | NM_004467 NP_004458.3 Q08830 |
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