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DPF1 / Neuro-D4
D4, zinc and double PHD fingers family 1
May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
| Gene Name: | D4, zinc and double PHD fingers family 1 |
| Synonyms: | DPF1, BAF45b, BRG1-associated factor 45B, NEUD4, Neuro-d4, Neuro-d4 homolog, Zinc finger protein neuro-d4 |
| Target Sequences: | NM_004647 NP_004638.2 Q92782 |
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