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Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.
Gene Name: | dedicator of cytokinesis 2 |
Synonyms: | DOCK2, Dedicator of cyto-kinesis 2, Dedicator of cytokinesis 2, KIAA0209 |
Target Sequences: | D86964 Q92608 Q92608 |
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