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Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
Gene Name: | DNA (cytosine-5-)-methyltransferase 3 alpha |
Synonyms: | DNMT3A, DNA MTase HsaIIIA, DNMT3A2, DNA methyltransferase HsaIIIA, M.HsaIIIA |
Target Sequences: | NM_022552 NP_072046.2 Q9Y6K1 |
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