DMRT1 antibody LS-C502224 is an HRP-conjugated rabbit polyclonal antibody to human DMRT1. Validated for ELISA.
(tested or 100% immunogen sequence identity)
Also available Unconjugated
or conjugated with FITC
Protein G purified
- (applications tested for the base form of this product only)
DMRT1 antibody was raised against recombinant Human Doublesex- and mab-3-related transcription factor 1 protein (195-363AA)
Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity).
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
For research use only.