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DDR2

discoidin domain receptor tyrosine kinase 2

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.

Gene Name: discoidin domain receptor tyrosine kinase 2
Family/Subfamily: Protein Kinase , DDR/TKT
Synonyms: DDR2, CD167b antigen, Discoidin domain receptor 2, Hydroxyaryl-protein kinase, MIG20a, Tyrosine-protein kinase TYRO10, NTRKR3, TYRO10, Tyrosylprotein kinase
Target Sequences: NM_006182 NP_006173.2 Q16832

Publications (6)

1
Region and cell-type resolved quantitative proteomic map of the human heart. Doll S, Dreßen M, Geyer PE, Itzhak DN, Braun C, Doppler SA, Meier F, Deutsch MA, Lahm H, Lange R, Krane M, Mann M. Nature communications. 2017 November;8:1469. (Human) [Full Text Article] [PubMed:29133944] [PMC:PMC5684139] Related Antibodies: LS-C99151.
2
Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers. Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM, Werb Z. Genes & development. 2018 February;32:244-257. [Full Text Article] [PubMed:29483153] [PMC:PMC5859966] Related Antibodies: LS-C164363.
3
Targeting extracellular vesicles to injured tissue using membrane cloaking and surface display. Travis J Antes, Ryan C Middleton, Kristin M Luther, Takeshi Ijichi, Kiel A Peck, Weixin Jane Liu, Jackie Valle, Antonio K Echavez, Eduardo Marbán. Journal of nanobiotechnology. 2018 Aug;16:61. [Full Text Article] [PubMed:30165851] [PMC:PMC6116387] Related Antibodies: LS-C255960.
4
Cardiac Mesenchymal Stem Cells Promote Fibrosis and Remodeling in Heart Failure: Role of PDGF Signaling. Tariq Hamid, Yuanyuan Xu, Mohamed Ameen Ismahil, Gregg Rokosh, Miki Jinno, Guihua Zhou, Qiongxin Wang, Sumanth D Prabhu. JACC. Basic to translational science. 2022 May;7:465-483. [Full Text Article] [PubMed:35663630] [PMC:PMC9156441] Related Antibodies: LS-C255961.
5
The collagen receptor, discoidin domain receptor 2, functions in Gli1-positive skeletal progenitors and chondrocytes to control bone development. Fatma F Mohamed, Chunxi Ge, Randy T Cowling, Daniel Lucas, Shawn A Hallett, Noriaki Ono, Abdul-Aziz Binrayes, Barry Greenberg, Renny T Franceschi. Bone research. 2022 February;10:11. [Full Text Article] [PubMed:35140200] [PMC:PMC8828874] Related Antibodies: LS-B15752.
6
Synthetic peptides activating discoidin domain receptor 2 and collagen-binding integrins cooperate to stimulate osteoblast differentiation of skeletal progenitor cells. Chunxi Ge, Yiming Li, Fashuai Wu, Peter Ma, Renny T Franceschi. Acta biomaterialia. 2023 August;166:109-118. [Full Text Article] [PubMed:37245640] [PMC:PMC10643765] Related Antibodies: LS-B15752.
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☰ Filters
Antibodies (40)
Proteins (21)
ELISA Kits (5)
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Over-Expression Lysate (6)
Primary (40)
Recombinant (15)
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DDR2 (66)
Human (32)
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IHC (16)
IHC-P (9)
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ELISA (23)
ICC (1)
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rabbit (36)
mouse (4)
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IgG2a (3)
monoclonal mc (4)
polyclonal pc (36)
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aa290-320 (2)
aa834-855 (1)
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Low endotoxin level (8)
DDR2 Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE), at a concentration of 10 ug/ml.
Select
DDR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
Select
DDR2 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
DDR2 Antibody - Anti-DDR2 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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DDR2 Mouse anti-Human Monoclonal (3B11E4) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
DDR2 Antibody - Formalin-fixed and paraffin-embedded human normal lung with TYRO10 Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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DDR2 Rabbit anti-Human Polyclonal Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
DDR2 Antibody - Mouse Ddr2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded mouse heart tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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DDR2 Rabbit anti-Mouse Polyclonal (aa816-843) Antibody
Mouse
IHC, IHC-P, WB
Unconjugated
400 µl/$393
DDR2 Antibody - DDR2 Antibody western blot of HepG2 cell line lysates (35 ug/lane). The DDR2 antibody detected the DDR2 protein (arrow).
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DDR2 Mouse anti-Human Monoclonal (aa290-320) Antibody
Human
WB
Unconjugated
0.1 ml/$393
DDR2 Antibody - Western blot analysis of extracts of various cell lines, using DDR2 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 30s.
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DDR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
DDR2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
DDR2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$764
DDR2 Antibody - DDR2 Antibody in Immunohistochemistry (IHC)
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DDR2 Mouse anti-Human Monoclonal (3B11E4) Antibody
Human
ICC, IF, IHC, WB
Unconjugated
100 µl/$541
DDR2 Antibody - Immunohistochemistry (IHC) analysis of paraffin-embedded human skeletal Muscle tissues with AEC staining using DDR2 Monoclonal Antibody.
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DDR2 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
DDR2 Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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DDR2 Rabbit anti-Human Polyclonal (aa578-817) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
DDR2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
DDR2 Antibody - IHC staining of FFPE mouse small intestine with DDR2 antibody at 2ug/ml. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.
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DDR2 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
ELISA, IHC-P, WB
Unconjugated
100 µg/$575
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DDR2 Rabbit anti-Mouse Polyclonal (aa816-843) Antibody
Mouse
IHC, WB
Unconjugated
200 µl/$734
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DDR2 Rabbit anti-Mouse Polyclonal (aa816-843) (Biotin) Antibody
Mouse
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
Select
DDR2 Rabbit anti-Mouse Polyclonal (aa816-843) (FITC) Antibody
Mouse
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
Select
DDR2 Rabbit anti-Mouse Polyclonal (aa816-843) (APC) Antibody
Mouse
ELISA, IHC, WB
APC Conjugated
200 µl/$952
Select
DDR2 Rabbit anti-Mouse Polyclonal (aa816-843) (Azide-free) (HRP) Antibody
Mouse
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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DDR2 Rabbit anti-Mouse Polyclonal (aa816-843) (PE) Antibody
Mouse
ELISA, IHC, WB
PE Conjugated
200 µl/$952
DDR2 Antibody - IHC analysis of DDR2 using anti-DDR2 antibody. DDR2 was detected in paraffin-embedded section of mouse small intestine tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 2µg/ml rabbit anti-DDR2 Antibody overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
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DDR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
DDR2 Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using DDR2 Polyclonal Antibody at dilution of 1:40.
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DDR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
DDR2 Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using DDR2 Polyclonal Antibody at dilution of 1:40.
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DDR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
DDR2 Antibody - Immunohistochemical analysis of paraffin-embedded human-lung-cancer, antibody was diluted at 1:200.
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DDR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Select
DDR2 Rabbit anti-Mouse Polyclonal (Preservative Free) Antibody
Mouse
ELISA, IHC-P
Unconjugated, Preservative Free
100 µl/$412
Viewing 1-25 of 66 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).