Human DCN / Decorin

Rabbit

Human, Mouse, Rat, Bat, Dog, Guinea pig, Hamster, Horse, Pig (tested or 100% immunogen sequence identity)

Rabbit (at least 90% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Immunoaffinity purified

Unmodified

Synthetic peptide from the C-Terminus of human Decorin (TFRCVYVRSAIQLGNYK, aa343-359 of UniProt P07585) was used as the immunogen for this Decorin antibody. Percent identity by BLAST analysis: Human, Mouse, Ferret, Cat, Bat, Hamster, Elephant, Horse, Pig, Guinea pig, Dog (100%); Rabbit, Opossum (94%); Sheep, Bovine, Goat, Platypus, Xenopus (88%); Rat, Trout, Salmon, Pufferfish, Zebrafish, Stickleback (82%).

aa343-359

Human DCN / Decorin

• Western blot (0.5 - 1 µg/ml)

Decorin is a proteoglycan on average 90-140 kilodaltons (kD) in size. The human decorin gene spans more than 38 kb and contains 8 exons and very large introns, 2 of which are 5.4 and more than 13.2 kb. And the human decorin gene is mapped to 12q21.3. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a protein core containing leucine repeats with a glycosaminoglycan (GAG) chain consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS). Decorin is a small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. Decorin and biglycan are though to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. And it also may play a role in epithelial/mesenchymal interactions during organ development and shaping. Decorin has been shown to have anti-tumorigenic properties in an experimental murine tumor model and is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for the decorin gene. Mutations in the decorin gene are associated with congenital stromal corneal dystrophy.

Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.

Reconstitute in sterile distilled water.

Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P07585 NCBI: NM_001920 NP_001911.1