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Cysteinyl leukotriene receptor 1, a Chemoattractant Receptor, is detected in spleen, peripheral blood leukocytes, and lung smooth muscle (Lynch et al., 1999). It binds cysteinyl leukotrienes, which are neutrophil chemoattractants with potent proinflammatory action. Leukotrienes mediate many features of bronchial asthma such as edema, bronchial constriction, and hyperreactivity ( Bisgaard et al., 2000). Selective CysLT1 antagonists are used to treat asthma.
Gene Name: | cysteinyl leukotriene receptor 1 |
Family/Subfamily: | GPCR , Chemoattractant |
Synonyms: | CYSLTR1, Cys-LT1 receptor, CysLT(1), Cys-leukotriene-1 receptor, CYSLT1, CYSLT1R, CYSLTR, HG55, LTD4 receptor, HMTMF81, Cysteinyl lt1 receptor |
Target Sequences: | NM_006639 NP_006630.1 Q9Y271 |
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