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CTSH / Cathepsin H is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors.
Gene Name: | cathepsin H |
Family/Subfamily: | Protease , Cysteine C1 |
Synonyms: | CTSH, Aleurain, Cathepsin B3, Cathepsin BA, Cathepsin H, CPSB, ACC-4, ACC-5, Minichain, Pro-cathepsin H |
Target Sequences: | NM_004390 NP_004381.2 P09668 |
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