Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
ERCC8 antibody LS-B4076 is an unconjugated rabbit polyclonal antibody to ERCC8 (CSA) from human, mouse, rat and other species. Validated for ICC, IF, IHC and WB. Tested on 20 paraffin-embedded human tissues.
Human, Mouse, Rat, Bovine
(tested or 100% immunogen sequence identity)
IHC - Paraffin (10 µg/ml)
Immunofluorescence (1:100 - 1:200)
Western blot (1:500 - 1:3000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
CSA / ERCC8 antibody was raised against recombinant protein fragment containing a sequence corresponding to a region within amino acids 106 and 300 of CSA.
Cross reactivity with mouse has been confirmed in WB only. The suitability of the antibody for use in IHC with mouse samples has not been evaluated at this time. Cross-reactivity with rat and cow has not been experimentally confirmed. The antibody is predicted to cross-react with rat and cow based on sequence homologies of 96% and 95% respectively.
Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair.