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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ClC‑5 / CLCN5 Antibody (C‑Terminus) LS‑C6131
CLCN5 antibody LS-C6131 is an unconjugated rabbit polyclonal antibody to CLCN5 (ClC-5) from human and rat. Validated for ELISA and WB.
Antibody
Catalog
Size
Price
LS-C6131-100
100 µl
$725

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Applications: IHC, Western blot

Product Description

CLCN5 antibody LS-C6131 is an unconjugated rabbit polyclonal antibody to CLCN5 (ClC-5) from human and rat. Validated for ELISA and WB.
About ClC-5 / CLCN5
Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function. P51795 NM_000084 NP_000075.1

CLCN5 Antibody, DENTS Antibody, CLC5 Antibody, HCIC-K2 Antibody, Nephrolithiasis 1 (X-linked) Antibody, Nephrolithiasis 2, X-linked Antibody, NPHL1 Antibody, NPHL2 Antibody, XLRH Antibody, XRN Antibody, Chloride channel 5 Antibody, Chloride channel protein 5 Antibody, Chloride transporter ClC-5 Antibody, ClC-5 Antibody, CLCK2 Antibody, HClC-K2 Antibody


Specifications

Target
Rat ClC-5 / CLCN5
Host
Rabbit
Reactivity
Rat, Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Antiserum
Modifications
Unmodified
Applications
  • Western blot (1:1000 - 1:5000)
  • ELISA (1:10000 - 1:50000)
Immunogen
ClC-5 / CLCN5 antibody was raised against a 13 AA Peptide sequence near the C-terminus of rat CLC-5 (1). The peptide was coupled to KLH.
Epitope
C-Terminus
Specificity
The 13 AA CLC51-P control peptide is 100% conserved in rat and human CLC-5. No significant sequence homology is detected with other CLCs or other proteins. Actual cross-reactivity of antibodies in various species has not been studied. There is a very high degree of protein homology among CLC-3, CLC-4 and CLC-5. However, CLC51-P peptide has very little sequence homology with CLC-3 and CLC-4. Anti-rat CLC41 antibodies were checked against the corresponding CLC-3 and CLC-4. These peptides are also available to confirm specificity of antibodies.
Usage
Suitable for use in ELISA, Western Blot. Western Blot: 1:1000-1:5000 for neat serum and 1-10 ug/ml for affinity pure antibody using ECL. Antibodies made to various CLC-5 peptides have been shown to detect a protein of approx. 80kD in kidney. ELISA:1:10000-1:50000 for neat serum and 0.5-1 ug/ml for affinity purified. Control peptide can be used to coat ELISA plates at 1 ug/ml.
Presentation
PBS, 0.05% Sodium Azide
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: United States
Date Requested: 8/15/2018

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