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Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no activity toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substrate specificity may be influenced by its subcellular location.
Gene Name: | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 |
Synonyms: | CHST5, GlcNAc6ST-3, GST4-alpha, Gn6st-3, HIGn6ST, I-GlcNAc-6-ST, I-GlcNAc6ST |
Target Sequences: | NM_024533 NP_078809.2 Q9GZS9 |
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